Nemudryi lab RNA editing - RNA repair - RNA viruses

Publications


To view a complete list of Dr. Nemudryi’s publications, please visit Google Scholar or PubMed.

2024

Repair of CRISPR-guided RNA breaks enables site-specific RNA excision in human cells
Repair of CRISPR-guided RNA breaks enables site-specific RNA excision in human cells
Anna Nemudraia, Artem Nemudryi, Blake Wiedenheft
Science  ·  25 Apr 2024  ·  doi:10.1126/science.adk5518
Genome Engineering Seminar Series, Harvard Medical School
The Diverse Evolutionary Histories of Domesticated Metaviral Capsid Genes in Mammals
William S Henriques, Janet M Young, Artem Nemudryi, Anna Nemudraia, Blake Wiedenheft, Harmit S Malik
Molecular Biology and Evolution  ·  20 Mar 2024  ·  10.1093/molbev/msae061

2023

CRISPR-based engineering of RNA viruses
CRISPR-based engineering of RNA viruses
Artem Nemudryi, Anna Nemudraia, Joseph E. Nichols, Andrew M. Scherffius, Trevor Zahl, Blake Wiedenheft
Science Advances  ·  15 Sep 2023  ·  doi:10.1126/sciadv.adj8277
CRISPR-Based Editing of RNA Viruses Developed, Inside Precision Medicine
RNA editing set to democratise viral engineering, Chemistry World
Discussion on TWiV 1045 (from 34:11)
Repair of CRISPR-guided RNA breaks enables site-specific RNA editing in human cells
Repair of CRISPR-guided RNA breaks enables site-specific RNA editing in human cells
Anna Nemudraia, Artem Nemudryi, Blake Wiedenheft
bioRxiv  ·  29 Aug 2023  ·  doi:10.1101/2023.08.29.555404
Polyamines and linear DNA mediate bacterial threat assessment of bacteriophage infection
Polyamines and linear DNA mediate bacterial threat assessment of bacteriophage infection
Camilla D. de Mattos, Dominick R. Faith, Artem A. Nemudryi, Amelia K. Schmidt, DeAnna C. Bublitz, …, Jumpei Uchiyama, Laura K. Jennings, Prahathees Eswara, Blake Wiedenheft, Patrick R. Secor
Proceedings of the National Academy of Sciences  ·  21 Feb 2023  ·  doi:10.1073/pnas.2216430120

2022

Sequence-specific capture and concentration of viral RNA by type III CRISPR system enhances diagnostic
Sequence-specific capture and concentration of viral RNA by type III CRISPR system enhances diagnostic
Anna Nemudraia, Artem Nemudryi, Murat Buyukyoruk, Andrew M. Scherffius, Trevor Zahl, …, Laura R. Snyder, Joshua D. Jones, Kristin S. Koutmou, Andrew Santiago-Frangos, Blake Wiedenheft
Nature Communications  ·  15 Dec 2022  ·  doi:10.1038/s41467-022-35445-5
A viral “codebreaker” intercepts a host alarm
A viral “codebreaker” intercepts a host alarm
Artem Nemudryi, Anna Nemudraia, Tanner Wiegand, Samuel H. Sternberg, Blake Wiedenheft
Cell Host & Microbe  ·  01 Dec 2022  ·  doi:10.1016/j.chom.2022.11.005
The Rise and Fall of SARS-CoV-2 Variants and Ongoing Diversification of Omicron
The Rise and Fall of SARS-CoV-2 Variants and Ongoing Diversification of Omicron
Tanner Wiegand, Artem Nemudryi, Anna Nemudraia, Aidan McVey, Agusta Little, David N. Taylor, Seth T. Walk, Blake Wiedenheft
Viruses  ·  10 Sep 2022  ·  doi:10.3390/v14092009
CRISPR-Cas, Argonaute proteins and the emerging landscape of amplification-free diagnostics
CRISPR-Cas, Argonaute proteins and the emerging landscape of amplification-free diagnostics
Andrew Santiago-Frangos, Artem Nemudryi, Anna Nemudraia, Tanner Wiegand, Joseph E. Nichols, Pushya Krishna, Andrew M. Scherffius, Trevor R. Zahl, Royce A. Wilkinson, Blake Wiedenheft
Methods  ·  01 Sep 2022  ·  doi:10.1016/j.ymeth.2022.06.002
Severe Acute Respiratory Syndrome Coronavirus 2 Is Detected in the Gastrointestinal Tract of Asymptomatic Endoscopy Patients but Is Unlikely to Pose a Significant Risk to Healthcare Personnel
Michelle D. Cherne, Andrew B. Gentry, Anna Nemudraia, Artem Nemudryi, Jodi F. Hedges, …, David B. King, Raina K. Plowright, Mark A. Jutila, Blake Wiedenheft, Diane Bimczok
Gastro Hep Advances  ·  01 Jan 2022  ·  10.1016/j.gastha.2022.06.002

2021

SARS-CoV-2 genomic surveillance identifies naturally occurring truncation of ORF7a that limits immune suppression
SARS-CoV-2 genomic surveillance identifies naturally occurring truncation of ORF7a that limits immune suppression
Artem Nemudryi, Anna Nemudraia, Tanner Wiegand, Joseph Nichols, Deann T. Snyder, …, Helen Lee, Karl K. Vanderwood, Diane Bimczok, Mark A. Jutila, Blake Wiedenheft
Cell Reports  ·  01 Jun 2021  ·  doi:10.1016/j.celrep.2021.109197
MSU researchers publish study on coronavirus variant, MSU News Service
Intrinsic signal amplification by type III CRISPR-Cas systems provides a sequence-specific SARS-CoV-2 diagnostic
Intrinsic signal amplification by type III CRISPR-Cas systems provides a sequence-specific SARS-CoV-2 diagnostic
Andrew Santiago-Frangos, Laina N. Hall, Anna Nemudraia, Artem Nemudryi, Pushya Krishna, …, Helen H. Lee, Ava Graham, Mark A. Jutila, Matthew P. Taylor, Blake Wiedenheft
Cell Reports Medicine  ·  01 Jun 2021  ·  doi:10.1016/j.xcrm.2021.100319

2020

Temporal Detection and Phylogenetic Assessment of SARS-CoV-2 in Municipal Wastewater
Temporal Detection and Phylogenetic Assessment of SARS-CoV-2 in Municipal Wastewater
Artem Nemudryi, Anna Nemudraia, Tanner Wiegand, Kevin Surya, Murat Buyukyoruk, Calvin Cicha, Karl K. Vanderwood, Royce Wilkinson, Blake Wiedenheft
Cell Reports Medicine  ·  01 Sep 2020  ·  doi:10.1016/j.xcrm.2020.100098
Sewers Are Now a COVID-19 Early-Warning System, The Atlantic

2018

CRISPR RNA-guided autonomous delivery of Cas9
CRISPR RNA-guided autonomous delivery of Cas9
Royce A. Wilkinson, Coleman Martin, Artem A. Nemudryi, Blake Wiedenheft
Nature Structural & Molecular Biology  ·  31 Dec 2018  ·  doi:10.1038/s41594-018-0173-y